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sr 717  (MedChemExpress)


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    Structured Review

    MedChemExpress sr 717
    Cabozantinib and STING activation in macrophages favor macrophage reprograming enhancing antitumor immunity. A In THP-1–activated macrophages, cabozantinib (5µM) induced expression of type I interferon-stimulated genes (ISGs) CXCL10 , MX1 , RSAD , and OAS1 , being abrogated by STING inhibitor H-151 (1µM) ( n = 3). B STING <t>agonist</t> <t>SR-717</t> (5µM) strongly induction ISGs in THP-1 cells ( n = 3). C Murine peritoneal macrophages were obtained and treated with cabozantinib (10µM) and STING agonist DMXAA. mRNA levels indicative of M1/M2 polarization were determined after 24 h. ( n = 4). Student t test or one-way ANOVA with a Newman-Keuls post hoc test with * p < 0.05, ** p < 0.01. * p < 0.05,
    Sr 717, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sr 717/product/MedChemExpress
    Average 94 stars, based on 7 article reviews
    sr 717 - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Immune remodeling via mitochondria-dependent STING activation enhances cabozantinib response in hepatocellular carcinoma"

    Article Title: Immune remodeling via mitochondria-dependent STING activation enhances cabozantinib response in hepatocellular carcinoma

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    doi: 10.1186/s13046-025-03632-z

    Cabozantinib and STING activation in macrophages favor macrophage reprograming enhancing antitumor immunity. A In THP-1–activated macrophages, cabozantinib (5µM) induced expression of type I interferon-stimulated genes (ISGs) CXCL10 , MX1 , RSAD , and OAS1 , being abrogated by STING inhibitor H-151 (1µM) ( n = 3). B STING agonist SR-717 (5µM) strongly induction ISGs in THP-1 cells ( n = 3). C Murine peritoneal macrophages were obtained and treated with cabozantinib (10µM) and STING agonist DMXAA. mRNA levels indicative of M1/M2 polarization were determined after 24 h. ( n = 4). Student t test or one-way ANOVA with a Newman-Keuls post hoc test with * p < 0.05, ** p < 0.01. * p < 0.05,
    Figure Legend Snippet: Cabozantinib and STING activation in macrophages favor macrophage reprograming enhancing antitumor immunity. A In THP-1–activated macrophages, cabozantinib (5µM) induced expression of type I interferon-stimulated genes (ISGs) CXCL10 , MX1 , RSAD , and OAS1 , being abrogated by STING inhibitor H-151 (1µM) ( n = 3). B STING agonist SR-717 (5µM) strongly induction ISGs in THP-1 cells ( n = 3). C Murine peritoneal macrophages were obtained and treated with cabozantinib (10µM) and STING agonist DMXAA. mRNA levels indicative of M1/M2 polarization were determined after 24 h. ( n = 4). Student t test or one-way ANOVA with a Newman-Keuls post hoc test with * p < 0.05, ** p < 0.01. * p < 0.05,

    Techniques Used: Activation Assay, Expressing



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    Cabozantinib and STING activation in macrophages favor macrophage reprograming enhancing antitumor immunity. A In THP-1–activated macrophages, cabozantinib (5µM) induced expression of type I interferon-stimulated genes (ISGs) CXCL10 , MX1 , RSAD , and OAS1 , being abrogated by STING inhibitor H-151 (1µM) ( n = 3). B STING <t>agonist</t> <t>SR-717</t> (5µM) strongly induction ISGs in THP-1 cells ( n = 3). C Murine peritoneal macrophages were obtained and treated with cabozantinib (10µM) and STING agonist DMXAA. mRNA levels indicative of M1/M2 polarization were determined after 24 h. ( n = 4). Student t test or one-way ANOVA with a Newman-Keuls post hoc test with * p < 0.05, ** p < 0.01. * p < 0.05,
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    Image Search Results


    Cabozantinib and STING activation in macrophages favor macrophage reprograming enhancing antitumor immunity. A In THP-1–activated macrophages, cabozantinib (5µM) induced expression of type I interferon-stimulated genes (ISGs) CXCL10 , MX1 , RSAD , and OAS1 , being abrogated by STING inhibitor H-151 (1µM) ( n = 3). B STING agonist SR-717 (5µM) strongly induction ISGs in THP-1 cells ( n = 3). C Murine peritoneal macrophages were obtained and treated with cabozantinib (10µM) and STING agonist DMXAA. mRNA levels indicative of M1/M2 polarization were determined after 24 h. ( n = 4). Student t test or one-way ANOVA with a Newman-Keuls post hoc test with * p < 0.05, ** p < 0.01. * p < 0.05,

    Journal: Journal of Experimental & Clinical Cancer Research : CR

    Article Title: Immune remodeling via mitochondria-dependent STING activation enhances cabozantinib response in hepatocellular carcinoma

    doi: 10.1186/s13046-025-03632-z

    Figure Lengend Snippet: Cabozantinib and STING activation in macrophages favor macrophage reprograming enhancing antitumor immunity. A In THP-1–activated macrophages, cabozantinib (5µM) induced expression of type I interferon-stimulated genes (ISGs) CXCL10 , MX1 , RSAD , and OAS1 , being abrogated by STING inhibitor H-151 (1µM) ( n = 3). B STING agonist SR-717 (5µM) strongly induction ISGs in THP-1 cells ( n = 3). C Murine peritoneal macrophages were obtained and treated with cabozantinib (10µM) and STING agonist DMXAA. mRNA levels indicative of M1/M2 polarization were determined after 24 h. ( n = 4). Student t test or one-way ANOVA with a Newman-Keuls post hoc test with * p < 0.05, ** p < 0.01. * p < 0.05,

    Article Snippet: Cabozantinib, Lenvatinib (HY-10981), H-151 (HY-112693), DMXAA (HY10964), SR-717 ( HY131454 ), MSA-2 ( HY136927 ), were from MedChem Express (Monmouth Junction, NJ, USA).

    Techniques: Activation Assay, Expressing